Overview
Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics at the Russian Academy of Sciences. It is an elongated version of the naturally occurring tetrapeptide Tuftsin, featuring an added Pro-Gly-Pro sequence that enhances its metabolic stability and duration of action. Unlike traditional anxiolytics, it is designed to provide relief from stress and anxiety without the typical side effects of sedation, cognitive impairment, or physical dependence.
Beyond its psychological applications, Selank acts as a nootropic by stimulating the expression of Brain-Derived Neurotrophic Factor (BDNF) and modulating neurotransmitters like serotonin and dopamine. It also demonstrates unique immunomodulatory properties due to its structural relationship with IgG antibodies, potentially influencing the body's inflammatory response. It is most commonly administered via nasal spray to bypass the blood-brain barrier effectively.
Mechanism of action
Acts as a synthetic analog of the immunomodulatory peptide Tuftsin; it functions as an allosteric modulator of GABA receptors and influences the metabolism of serotonin and dopamine.
Reported benefits
- ▸Reduced symptoms of Generalized Anxiety Disorder (GAD)
- ▸Improved cognitive focus and mental clarity
- ▸Enhanced mood regulation without sedative effects消
- ▸Potential immune system modulation via IL-6 regulation
- ▸Antistress effects through enkephalin release modulation
- ▸Improved learning and memory retention
Reported side effects
- ·Minimal reported toxicity
- ·Lack of sedative effects common in other anxiolytics
- ·Lack of withdrawal symptoms
Often stacked with
Semax